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Figure 2 | BMC Genomics

Figure 2

From: An integrated approach to characterize transcription factor and microRNA regulatory networks involved in Schwann cell response to peripheral nerve injury

Figure 2

Coexpressed gene clusters that are dynamically regulated during SC injury response. These gene clusters are enriched for functional categories involved in SC myelination and proliferation, and many of the genes annotated in these categories are potential targets of dynamically regulated miRNAs. (A) Expression profiles of the four dynamically regulated injury response gene clusters (IRGCs). (B) Gene Ontology terms enriched in each of the four IRGCs. Color coding of bars matches that of the expression profiles shown in (A). (C) Expression profiles of miRNAs that are anti-correlated with clusters 1 or 2 (red) and miRNAs that are anti-correlated with clusters 3 or 4 (blue) and. (D) The percentage of genes in the enriched functional categories that have a seed sequence match to dynamically regulated miRNAs. Enriched categories that have at least 50 % of the genes that are potential targets of dynamically regulated miRNAs are highlighted with grey bars.

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BMC Genomics

ISSN: 1471-2164

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