Figure 4

Validating computational TF target prediction using the compendium of TF ChIP-Seq datasets. (A) ChIP-Seq identified TF binding locations (peaks) within 15 kb around annotated mRNA transcription start sites (TSS) or predicted miRNA TSS were used to identify regulatory targets of TFs. Mann–Whitney U test was used to test if identified targets have higher binding scores calculated by the computational model. (B) Percent of ChIP-Seq datasets that were consistent with computational TF target prediction when tested using mouse or human mRNAs or miRNAs.