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Figure 8 | BMC Genomics

Figure 8

From: An integrated approach to characterize transcription factor and microRNA regulatory networks involved in Schwann cell response to peripheral nerve injury

Figure 8

The SC injury response regulatory subnetwork around Egr2 and Egr2 participating network motifs. (A) Upstream regulators and downstream targets of Egr2 and regulatory interactions among them. (B) Two feedforward loops found in the Egr2 subnetwork. These feedforward loops are likely to maintain the expression level of Hic1 within a small functional range. (C) Three feedback loops found in the Egr2 subnetwork. These feedback loops may function as modulators of Egr2 expression levels. Circles: TFs. Hexagons: miRNAs. Blue nodes: TFs or miRNAs correlated with myelination gene clusters. Red nodes: TFs or miRNAs correlated with proliferation gene clusters. Grey nodes: master TF or miRNA regulators of coexpressed genes. White boxes: downstream target genes not included in the network. Arrowed edges: activation by TFs. T-shaped edges: repression by TFs or miRNAs.

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