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Figure 3 | BMC Genomics

Figure 3

From: Morphogenesis-regulated localization of protein kinase A to genomic sites in Candida albicans

Figure 3

GO terms of genes associated with Tpk2 binding sites. A. Tpk2 binding sites during yeast growth. B. Tpk2 binding sites during hyphal induction. GO terms for Tpk2 binding targets were identified in ChIP chip data using the CGD GO Term Finder tool (http://www.candidagenome.org/cgi-bin/GO/goTermFinder). 1Genomic frequencies of genes corresponding to specific GO terms are expressed as percentages (gene number relative to 6,525 genes in the C. albicans genome [24]. Analysis conducted in April 2013. 2Gene name or ORF19 nomenclature according to CGD [24]. Some genes were attributed to more than one GO term. Red lettering: Tpk2 binding in ORF; blue lettering: Tpk2 binding in promoter and ORF; black lettering: Tpk2 binding in promoter a, b, cEfg1 binds to promoter regions in ayeast growth, bhyphal induction or cbiofilm induction [13, 25, 26]. d, eSet3 binding in dyeast or ehyphae inducing conditions [27]. 3Percentages were calculated based on the number of genes in each GO category divided by the total number (196 genes for Tpk2 in yeast form and 218 genes for Tpk2 in hyphal inducing conditions). 4P values for overrepresented categories were calculated using a hyper geometric distribution with multiple hypothesis correction according to the GO Term Finder tool website (http://www.candidagenome.org/help/goTermFinder.shtml). The P value cutoff used was 0.1. *Genes upregulated during hyphal induction [24, 28].

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