Table 1 Categories over-represented among the EGF regulated genes
From: Profiling and metaanalysis of epidermal keratinocytes responses to epidermal growth factor
Term | Count | PValue |
|---|---|---|
1Â h UP | ||
Dual specificity protein phosphatase | 5 | 7.42E-08 |
MAP kinase phosphatase | 5 | 4.38E-07 |
regulation of cell proliferation | 22 | 1.03E-06 |
MAP kinase tyrosine/serine/threonine phosphatase activity | 5 | 2.34E-06 |
regulation of transcription from RNA polymerase II promoter | 20 | 4.92E-06 |
Cell cycle control | 14 | 6.27E-06 |
regulation of apoptosis | 20 | 2.05E-05 |
Rhodanese-like | 5 | 2.06E-05 |
nuclear lumen | 24 | 2.14E-05 |
Cell proliferation and differentiation | 21 | 2.19E-05 |
Basic-leucine zipper (bZIP) transcription factor | 6 | 3.16E-05 |
organelle lumen | 27 | 3.32E-05 |
vasculature development | 11 | 3.44E-05 |
response to organic substance | 18 | 6.09E-05 |
JNK cascade | 6 | 8.69E-05 |
4Â h UP | ||
regulation of cell proliferation | 46 | 4.29E-15 |
regulation of cell motion | 22 | 1.30E-12 |
plasma membrane part | 68 | 8.83E-12 |
cell adhesion | 25 | 1.25E-10 |
vasculature development | 22 | 1.97E-10 |
plasma membrane | 91 | 2.71E-10 |
Focal adhesion | 23 | 2.71E-10 |
extracellular region part | 40 | 2.87E-10 |
signal | 75 | 1.24E-09 |
basement membrane | 12 | 6.78E-09 |
response to wounding | 29 | 6.99E-09 |
Signal transduction | 85 | 7.80E-09 |
integrin binding | 11 | 9.78E-09 |
24Â h UP | ||
Dual specificity protein phosphatase | 4 | 1.07E-05 |
Secreted | 26 | 2.04E-05 |
wound healing | 10 | 2.17E-05 |
angiogenesis | 9 | 2.37E-05 |
ectoderm development | 10 | 3.00E-05 |
disulfide bond | 36 | 3.23E-05 |
EGF-like region, conserved site | 11 | 3.30E-05 |
MAP kinase phosphatase | 4 | 3.62E-05 |
heparin-binding | 6 | 4.53E-05 |
regulation of cell migration | 9 | 6.13E-05 |
extracellular region part | 19 | 7.79E-05 |
Skin | 26 | 1.11E-04 |
epidermis development | 9 | 1.11E-04 |
signal | 37 | 1.25E-04 |
MAP kinase tyrosine/serine/threonine phosphatase activity | 4 | 1.43E-04 |
regulation of cell proliferation | 18 | 1.57E-04 |
Pathways in cancer | 13 | 1.79E-04 |
48Â h UP | ||
Metallothionein | 8 | 1.21E-12 |
acetylated amino end | 13 | 2.39E-11 |
16q13 | 8 | 5.32E-10 |
acetylation | 47 | 1.11E-07 |
Keratinocyte | 11 | 1.35E-07 |
response to protein stimulus | 9 | 1.08E-05 |
peptide cross-linking | 5 | 1.16E-04 |
Cajal-Retzius cell | 9 | 2.25E-04 |
Chaperone | 8 | 2.75E-04 |
Steroid biosynthesis | 5 | 2.81E-04 |
1q21 | 5 | 3.43E-04 |
Kidney | 26 | 5.22E-04 |
abdominal aortic aneurysm | 5 | 8.75E-04 |
1Â h DOWN | ||
glycoprotein | 81 | 8.14E-11 |
signal | 67 | 2.24E-10 |
plasma membrane part | 56 | 1.11E-09 |
disulfide bond | 59 | 1.15E-08 |
Secreted | 37 | 2.93E-06 |
calcium binding | 8 | 5.58E-05 |
extracellular region part | 26 | 5.75E-05 |
regulation of cell motion | 11 | 1.41E-04 |
Cell adhesion | 19 | 1.62E-04 |
defense response | 20 | 2.11E-04 |
calcium | 20 | 2.27E-04 |
Keratinocyte | 8 | 2.57E-04 |
sialic acid | 4 | 4.26E-04 |
disease mutation | 30 | 4.71E-04 |
Cell junction protein | 7 | 7.65E-04 |
response to wounding | 17 | 8.70E-04 |
apical part of cell | 9 | 9.02E-04 |
4Â h DOWN | ||
Ichthyosis | 7 | 3.02E-08 |
epidermis development | 12 | 2.90E-07 |
epithelial cell differentiation | 9 | 1.55E-05 |
cell cycle | 12 | 1.71E-04 |
Keratinocyte | 7 | 1.95E-04 |
Metabolism of xenobiotics by cytochrome P450 | 6 | 2.24E-04 |
epidermal cell differentiation | 6 | 2.94E-04 |
Foreskin | 5 | 4.58E-04 |
microsome | 6 | 5.75E-04 |
S100/CaBP-9Â k-type, calcium binding | 4 | 9.73E-04 |
disease mutation | 22 | 9.98E-04 |
24Â h DOWN | ||
Intermediate filament | 7 | 2.11E-06 |
Insulin-like growth factor binding protein, N-terminal | 4 | 3.13E-05 |
disease mutation | 21 | 6.00E-05 |
Thyroglobulin type-1 | 4 | 9.49E-05 |
Structural protein | 9 | 1.06E-04 |
response to abiotic stimulus | 11 | 1.11E-04 |
epidermis development | 8 | 1.67E-04 |
Aldehyde dehydrogenase NAD(P)-dependent | 3 | 1.68E-04 |
desmosome | 4 | 1.82E-04 |
response to steroid hormone stimulus | 8 | 2.17E-04 |
signal | 30 | 4.98E-04 |
Desmosomal cadherin | 3 | 5.82E-04 |
response to organic substance | 14 | 5.96E-04 |
keratin | 6 | 6.72E-04 |
48Â h DOWN | ||
phosphoprotein | 120 | 2.06E-10 |
response to organic substance | 33 | 1.73E-09 |
response to endogenous stimulus | 24 | 4.75E-09 |
regulation of programmed cell death | 34 | 8.33E-09 |
Cell cycle control | 23 | 1.43E-08 |
response to steroid hormone stimulus | 16 | 4.35E-08 |
negative regulation of apoptosis | 21 | 5.63E-08 |
response to hormone stimulus | 21 | 1.02E-07 |
apicolateral plasma membrane | 11 | 2.74E-07 |
Desmosomal cadherin | 5 | 5.95E-07 |
response to wounding | 23 | 2.37E-06 |
acetylation | 52 | 5.00E-06 |
response to extracellular stimulus | 14 | 8.15E-06 |
response to glucocorticoid stimulus | 9 | 9.28E-06 |
regulation of cell growth | 13 | 1.16E-05 |
response to nutrient | 11 | 1.83E-05 |