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Table 4 Biological processes common in the EGF-, EphrinAs- and SP600125-regulated genes

From: Profiling and metaanalysis of epidermal keratinocytes responses to epidermal growth factor

Gene ontology: Biological process

EGF 1&4 h UP

SP 1&4 h DN

EFNAs DN

biological process

3.94E-07

9.37E-02

6.92E-03

signal transduction

1.65E-05

1.75E-03

1

cell communication

1.94E-05

4.39E-03

5.49E-01

response to stress

6.39E-05

1

3.67E-02

cell motion

3.70E-03

1

3.70E-02

 

EGF 1&4 h DN

SP 1&4 h UP

EFNAs UP

epidermis development

8.64E-06

1

9.39E-09

response to external stimulus

5.47E-04

1.69E-06

1

tissue development

6.50E-04

9.01E-02

1.52E-05

cell differentiation

6.90E-04

4.87E-06

1.80E-07

keratinocyte differentiation

1.42E-02

3.14E-01

1.58E-11

defense response

2.05E-02

5.27E-02

1

response to chemical stimulus

2.22E-02

1.72E-13

1.23E-01

response to stress

2.32E-02

1.40E-07

1

 

EGF 24&48 h UP

SP 1&4 h DN

EFNAs DN

biological process

1.32E-02

9.37E-02

6.92E-03

metabolic process

3.16E-02

1.00E + 00

3.29E-02

anatomical structure development

4.50E-02

2.20E-01

1

blood coagulation

6.08E-02

3.59E-01

1

 

EGF 24&48 h DN

SP 1&4 h UP

EFNAs UP

response to stress

1.95E-06

5.34E-03

1

response to external stimulus

5.54E-04

1.08E-02

1

regulation of cell proliferati

2.87E-03

4.68E-06

1

epidermis development

5.18E-03

1

9.39E-09

response to wounding

8.27E-03

2.60E-02

1

biological process

1.45E-02

1.72E-03

5.83E-04

negative regulation of proliferation

1.56E-02

4.83E-02

1

tissue development

7.13E-02

1

1.52E-05

regulation of apoptosis

8.77E-02

9.18E-01

1

  1. UP denotes induced, DN suppressed genes. Note that the genes induced by EGF are suppressed by EphrinAs and SP600125, and vice versa.