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Table 4 Biological processes common in the EGF-, EphrinAs- and SP600125-regulated genes

From: Profiling and metaanalysis of epidermal keratinocytes responses to epidermal growth factor

Gene ontology: Biological process EGF 1&4 h UP SP 1&4 h DN EFNAs DN
biological process 3.94E-07 9.37E-02 6.92E-03
signal transduction 1.65E-05 1.75E-03 1
cell communication 1.94E-05 4.39E-03 5.49E-01
response to stress 6.39E-05 1 3.67E-02
cell motion 3.70E-03 1 3.70E-02
  EGF 1&4 h DN SP 1&4 h UP EFNAs UP
epidermis development 8.64E-06 1 9.39E-09
response to external stimulus 5.47E-04 1.69E-06 1
tissue development 6.50E-04 9.01E-02 1.52E-05
cell differentiation 6.90E-04 4.87E-06 1.80E-07
keratinocyte differentiation 1.42E-02 3.14E-01 1.58E-11
defense response 2.05E-02 5.27E-02 1
response to chemical stimulus 2.22E-02 1.72E-13 1.23E-01
response to stress 2.32E-02 1.40E-07 1
  EGF 24&48 h UP SP 1&4 h DN EFNAs DN
biological process 1.32E-02 9.37E-02 6.92E-03
metabolic process 3.16E-02 1.00E + 00 3.29E-02
anatomical structure development 4.50E-02 2.20E-01 1
blood coagulation 6.08E-02 3.59E-01 1
  EGF 24&48 h DN SP 1&4 h UP EFNAs UP
response to stress 1.95E-06 5.34E-03 1
response to external stimulus 5.54E-04 1.08E-02 1
regulation of cell proliferati 2.87E-03 4.68E-06 1
epidermis development 5.18E-03 1 9.39E-09
response to wounding 8.27E-03 2.60E-02 1
biological process 1.45E-02 1.72E-03 5.83E-04
negative regulation of proliferation 1.56E-02 4.83E-02 1
tissue development 7.13E-02 1 1.52E-05
regulation of apoptosis 8.77E-02 9.18E-01 1
  1. UP denotes induced, DN suppressed genes. Note that the genes induced by EGF are suppressed by EphrinAs and SP600125, and vice versa.