Table 6 Biological processes common in the EGF- and Retinoic acid-regulated genes
From: Profiling and metaanalysis of epidermal keratinocytes responses to epidermal growth factor
| a | |||
|---|---|---|---|
| Gene ontology: Biological process | EGF1&4hUP | RA 1hDN | |
| regulation of cell motion | 1.45E-07 | 5.00E-06 | |
| regulation of cell proliferation | 1.65E-07 | 3.06E-04 | |
| biological_process | 5.84E-07 | 1.68E-03 | |
| regulation of cell migration | 6.33E-05 | 1.69E-05 | |
| positive regulation of cell motility | 6.15E-04 | 1.43E-02 | |
| negative regulation of programed cell death | 6.27E-04 | 4.43E-02 | |
| positive regulation of cell migration | 4.30E-03 | 7.98E-03 | |
| anatomical structure development | 5.71E-02 | 5.33E-03 | |
| regulation of catalytic activity | 7.77E-02 | 3.55E-02 | |
| b | |||
| Gene ontology: Biological process | EGF1&4hUP | RA4hUP | |
| regulation of signal transduction | 1.41E-07 | 4.46E-04 | |
| biological_process | 5.84E-07 | 7.73E-05 | |
| regulation of gene expression | 2.27E-05 | 1.05E-04 | |
| signal transduction | 3.62E-05 | 3.42E-04 | |
| cell communication | 4.12E-05 | 2.77E-03 | |
| response to stress | 6.39E-05 | 8.06E-04 | |
| regulation of transcription | 7.87E-05 | 2.86E-04 | |
| negative regulation of programed cell death | 6.27E-04 | 4.51E-04 | |
| regulation of apoptosis | 8.12E-04 | 4.33E-02 | |
| response to external stimulus | 2.35E-03 | 4.24E-02 | |
| negative regulation of apoptosis | 3.07E-03 | 3.61E-04 | |
| positive regulation of signal transduction | 3.47E-03 | 4.51E-04 | |
| positive regulation of metabolism | 4.70E-03 | 1.99E-02 | |
| regulation of RNA metabolic process | 8.79E-03 | 4.78E-03 | |
| phosphate metabolic process | 1.08E-02 | 8.40E-05 | |
| regulation of transcription | 1.33E-02 | 6.50E-03 | |
| regulation of transcription | 1.59E-02 | 5.92E-03 | |
| positive regulation of gene expression | 3.33E-02 | 1.35E-02 | |
| protein metabolic process | 5.42E-02 | 1.39E-03 | |
| positive regulation of transcription | 9.37E-02 | 7.29E-03 | |
| EGF1&4hUP | RA24hUP | ||
| biological_process | 5.84E-07 | 1.20E-08 | |
| regulation of gene expression | 2.27E-05 | 1.57E-02 | |
| signal transduction | 3.62E-05 | 5.27E-04 | |
| cell communication | 4.12E-05 | 1.41E-03 | |
| response to stress | 6.39E-05 | 3.79E-04 | |
| regulation of transcription | 7.87E-05 | 6.83E-02 | |
| negative regulation of programed cell death | 6.27E-04 | 3.76E-04 | |
| regulation of apoptosis | 8.12E-04 | 1.03E-04 | |
| response to wounding | 8.17E-04 | 5.89E-04 | |
| response to external stimulus | 2.35E-03 | 4.81E-03 | |
| regulation of cell adhesion | 3.01E-03 | 3.76E-02 | |
| negative regulation of apoptosis | 3.07E-03 | 2.99E-04 | |
| positive regulation of signal transduction | 3.47E-03 | 3.66E-02 | |
| cell motion | 3.70E-03 | 7.55E-05 | |
| positive regulation of metabolism | 4.70E-03 | 7.30E-03 | |
| phosphate metabolic process | 1.08E-02 | 5.42E-02 | |
| protein metabolic process | 5.42E-02 | 6.91E-03 | |
| EGF24&48hUP | RA24hUP | ||
| cell differentiation | 5.90E-05 | 1.23E-02 | |
| biological_process | 1.32E-02 | 1.20E-08 | |
| metabolic process | 3.16E-02 | 1.43E-03 | |
| c | |||
| Kinase | EGF1&4hUP | RA1hDN | |
| MAPK1 | 2.51E-07 | 3.69E-03 | |
| MAPK14 | 1.36E-05 | 3.33E-03 | |
| MAPK3 | 1.70E-04 | 9.04E-05 | |
| EGF1&4hUP | RA4hUP | ||
| MAPK1 | 2.51E-07 | 3.31E-05 | |
| MAPK14 | 1.36E-05 | 1.45E-03 | |
| EGFR | 1.39E-05 | 6.66E-05 | |
| MAPK3 | 1.70E-04 | 2.29E-05 | |
| EGF1&4hUP | RA24hUP | ||
| EGFR | 1.39E-05 | 2.17E-06 | |
| INSR | 1.02E-04 | 2.86E-05 | |
| ERBB2 | 5.35E-02 | 8.18E-03 | |
| FYN | 5.36E-02 | 2.91E-02 | |
| d | |||
| T. F. | EGF1&4hUP | RA4hUP | RA24hUP |
| RELA | 2.28E-03 | 3.99E-02 | 3.34E-02 |
| REL | 4.41E-03 | 4.19E-05 | 9.16E-02 |