Figure 8
From: Reprogramming of lysosomal gene expression by interleukin-4 and Stat6
Effects of IL-4 and Stat6 on chromatin modifications near lysosomal genes. Analyses are based on publicly available ChIP-seq data deposited by Ostuni et al. (2013) [GEO:GSM1022256, GSM1022257, GSM1022258, GSM1022259, GSM1022264, GSM1022265, GSM1022266, GSM1022267] [58]. In that study bone marrow-derived macrophages from wild-type and Stat6-deficient mice were grown ± IL-4 for 4 hours, chromatin was immunoprecipitated with antibodies against Pu.1, H3K27ac and H3K4me1, and the DNA fragments were sequenced. Here, peak coordinates were annotated and aligned to selected genomic loci as in Figure 7. Peak regions are shown in orange (Stat6), red (Pu.1), green (H3K27ac) and purple (H3K4me1). Genomic regions and scales correspond to those shown in Figure 7.