Table 1 The distribution of the MTHFR 677 C > T genotype for case and control and the allele frequencies
First author | Year | Ethnical decent | Distribution of MTHFR genotypes (n(%)) | Frequency of MTHFR alleles (%) | P-valueHWE | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CC | CT | TT | C | T | |||||||||
Case | Control | Case | Control | Case | Control | Case | Control | Case | Control | ||||
Ndrepepa et al. [25] | 2008 | Germany | 225(44) | 690(43) | 215(42) | 740(46) | 67(13) | 184(11) | / | / | / | / | 0.49 |
Mazza et al. [12] | 2005 | Italy | 35(33) | 35(29) | 47(45) | 66(55) | 23(22) | 19(16) | / | / | / | / | 0.19 |
Bluthner et al. [26] | 1999 | Poland | 137(47) | 67(45) | 115(39) | 68(45) | 41(13) | 15(10) | / | 67 | / | 33 | 0.71 |
Benes et al. [27] | 2001 | Czech | 166(48) | 86(41) | 152(43) | 106(51) | 31(8) | 17(8) | 69 | 67 | 31 | 33 | 0.05 |
Yilmaz et al. [28] | 2004 | Turkish | 121(49) | 101(47) | 98(39) | 93(44) | 30(12) | 20(9) | 68 | 69 | 32 | 31 | 0.83 |
Eroglu et al. [29] | 2007 | Turkish | 51(50) | 63(49) | 45(44) | 58(45) | 7(7) | 7(6) | 71 | 71 | 29 | 29 | 0.17 |
Tutuncu et al. [30] | 2005 | Turkey | 41(45) | 52(52) | 39(43) | 43(43) | 11(12) | 5(5) | 60 | 70 | 40 | 30 | 0.29 |
Soares et al. [31] | 2007 | UK | 10(55) | 9(56) | 6(33) | 5(31) | 2(11) | 2(13) | / | / | / | / | 0.36 |
Angeline et al. [32] | 2009 | Indian | 88(73) | 80(80) | 32(27) | 20(20) | 0 | 0 | 88 | 90 | 12 | 10 | 0.57 |
Mehri et al. [33] | 2010 | Tunisian | 50(43) | 66(57) | 49(43) | 38(33) | 16(14) | 12(10) | 65 | 73 | 35 | 27 | 0.07 |
Sun et al. [34] | 2004 | Chinese | 102(46) | 74(57) | 76(35) | 34(26) | 42(19) | 22(17) | 64 | 70 | 56 | 30 | 0.001 |
Mtiraoui et al. [35] | 2007 | Tunisia | 163(45) | 270(68) | 135(38) | 94(24) | 62(17) | 36(9) | 64 | 79 | 36 | 21 | 0 |
Sun et al. [36] | 2003 | Chinese | 84(40) | 31(54) | 75(36) | 16(28) | 49(24) | 10(18) | 58 | 68 | 42 | 32 | 0.01 |
Movva, et al. [37] | 2011 | Indian | 68(68) | 91(91) | 32(32) | 9(9) | 0 | 0 | 84 | 95 | 16 | 4 | 0.05 |
Tavakkoly Bazzaz et al. [38] | 2010 | Iran | 148(53) | 113(55) | 102(36) | 80(39) | 31(11) | 14(7) | 71 | 76 | 26 | 24 | 0.21 |
Benrahma et al. [39] | 2012 | Morocco | 160(57) | 114(44) | 97(35) | 122(47) | 25(9) | 26(10) | 74 | 67 | 26 | 33 | 0.19 |
Sharaf et al. [40] | 2012 | Egypt | 24(48) | 13(65) | 17(34) | 5(25) | 9(18) | 2(10) | 65 | 78 | 35 | 22 | 0.13 |