|
First author
|
Year
|
Ethnical decent
|
Distribution of MTHFR genotypes (n(%))
|
Frequency of MTHFR alleles (%)
|
P-valueHWE
|
|---|
|
CC
|
CT
|
TT
|
C
|
T
|
|---|
|
Case
|
Control
|
Case
|
Control
|
Case
|
Control
|
Case
|
Control
|
Case
|
Control
|
|---|
|
Ndrepepa et al. [25]
|
2008
|
Germany
|
225(44)
|
690(43)
|
215(42)
|
740(46)
|
67(13)
|
184(11)
|
/
|
/
|
/
|
/
|
0.49
|
|
Mazza et al. [12]
|
2005
|
Italy
|
35(33)
|
35(29)
|
47(45)
|
66(55)
|
23(22)
|
19(16)
|
/
|
/
|
/
|
/
|
0.19
|
|
Bluthner et al. [26]
|
1999
|
Poland
|
137(47)
|
67(45)
|
115(39)
|
68(45)
|
41(13)
|
15(10)
|
/
|
67
|
/
|
33
|
0.71
|
|
Benes et al. [27]
|
2001
|
Czech
|
166(48)
|
86(41)
|
152(43)
|
106(51)
|
31(8)
|
17(8)
|
69
|
67
|
31
|
33
|
0.05
|
|
Yilmaz et al. [28]
|
2004
|
Turkish
|
121(49)
|
101(47)
|
98(39)
|
93(44)
|
30(12)
|
20(9)
|
68
|
69
|
32
|
31
|
0.83
|
|
Eroglu et al. [29]
|
2007
|
Turkish
|
51(50)
|
63(49)
|
45(44)
|
58(45)
|
7(7)
|
7(6)
|
71
|
71
|
29
|
29
|
0.17
|
|
Tutuncu et al. [30]
|
2005
|
Turkey
|
41(45)
|
52(52)
|
39(43)
|
43(43)
|
11(12)
|
5(5)
|
60
|
70
|
40
|
30
|
0.29
|
|
Soares et al. [31]
|
2007
|
UK
|
10(55)
|
9(56)
|
6(33)
|
5(31)
|
2(11)
|
2(13)
|
/
|
/
|
/
|
/
|
0.36
|
|
Angeline et al. [32]
|
2009
|
Indian
|
88(73)
|
80(80)
|
32(27)
|
20(20)
|
0
|
0
|
88
|
90
|
12
|
10
|
0.57
|
|
Mehri et al. [33]
|
2010
|
Tunisian
|
50(43)
|
66(57)
|
49(43)
|
38(33)
|
16(14)
|
12(10)
|
65
|
73
|
35
|
27
|
0.07
|
|
Sun et al. [34]
|
2004
|
Chinese
|
102(46)
|
74(57)
|
76(35)
|
34(26)
|
42(19)
|
22(17)
|
64
|
70
|
56
|
30
|
0.001
|
|
Mtiraoui et al. [35]
|
2007
|
Tunisia
|
163(45)
|
270(68)
|
135(38)
|
94(24)
|
62(17)
|
36(9)
|
64
|
79
|
36
|
21
|
0
|
|
Sun et al. [36]
|
2003
|
Chinese
|
84(40)
|
31(54)
|
75(36)
|
16(28)
|
49(24)
|
10(18)
|
58
|
68
|
42
|
32
|
0.01
|
|
Movva, et al. [37]
|
2011
|
Indian
|
68(68)
|
91(91)
|
32(32)
|
9(9)
|
0
|
0
|
84
|
95
|
16
|
4
|
0.05
|
|
Tavakkoly Bazzaz et al. [38]
|
2010
|
Iran
|
148(53)
|
113(55)
|
102(36)
|
80(39)
|
31(11)
|
14(7)
|
71
|
76
|
26
|
24
|
0.21
|
|
Benrahma et al. [39]
|
2012
|
Morocco
|
160(57)
|
114(44)
|
97(35)
|
122(47)
|
25(9)
|
26(10)
|
74
|
67
|
26
|
33
|
0.19
|
|
Sharaf et al. [40]
|
2012
|
Egypt
|
24(48)
|
13(65)
|
17(34)
|
5(25)
|
9(18)
|
2(10)
|
65
|
78
|
35
|
22
|
0.13
|
- The significance level (p-value) for Hardy-Weinberg equilibrium (HWE) testing for controls is shown.
