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Table 1 The distribution of the MTHFR 677 C > T genotype for case and control and the allele frequencies

From: Association of homocysteine with type 2 diabetes: a meta-analysis implementing Mendelian randomization approach

First author Year Ethnical decent Distribution of MTHFR genotypes (n(%)) Frequency of MTHFR alleles (%) P-valueHWE
CC CT TT C T
Case Control Case Control Case Control Case Control Case Control
Ndrepepa et al. [25] 2008 Germany 225(44) 690(43) 215(42) 740(46) 67(13) 184(11) / / / / 0.49
Mazza et al. [12] 2005 Italy 35(33) 35(29) 47(45) 66(55) 23(22) 19(16) / / / / 0.19
Bluthner et al. [26] 1999 Poland 137(47) 67(45) 115(39) 68(45) 41(13) 15(10) / 67 / 33 0.71
Benes et al. [27] 2001 Czech 166(48) 86(41) 152(43) 106(51) 31(8) 17(8) 69 67 31 33 0.05
Yilmaz et al. [28] 2004 Turkish 121(49) 101(47) 98(39) 93(44) 30(12) 20(9) 68 69 32 31 0.83
Eroglu et al. [29] 2007 Turkish 51(50) 63(49) 45(44) 58(45) 7(7) 7(6) 71 71 29 29 0.17
Tutuncu et al. [30] 2005 Turkey 41(45) 52(52) 39(43) 43(43) 11(12) 5(5) 60 70 40 30 0.29
Soares et al. [31] 2007 UK 10(55) 9(56) 6(33) 5(31) 2(11) 2(13) / / / / 0.36
Angeline et al. [32] 2009 Indian 88(73) 80(80) 32(27) 20(20) 0 0 88 90 12 10 0.57
Mehri et al. [33] 2010 Tunisian 50(43) 66(57) 49(43) 38(33) 16(14) 12(10) 65 73 35 27 0.07
Sun et al. [34] 2004 Chinese 102(46) 74(57) 76(35) 34(26) 42(19) 22(17) 64 70 56 30 0.001
Mtiraoui et al. [35] 2007 Tunisia 163(45) 270(68) 135(38) 94(24) 62(17) 36(9) 64 79 36 21 0
Sun et al. [36] 2003 Chinese 84(40) 31(54) 75(36) 16(28) 49(24) 10(18) 58 68 42 32 0.01
Movva, et al. [37] 2011 Indian 68(68) 91(91) 32(32) 9(9) 0 0 84 95 16 4 0.05
Tavakkoly Bazzaz et al. [38] 2010 Iran 148(53) 113(55) 102(36) 80(39) 31(11) 14(7) 71 76 26 24 0.21
Benrahma et al. [39] 2012 Morocco 160(57) 114(44) 97(35) 122(47) 25(9) 26(10) 74 67 26 33 0.19
Sharaf et al. [40] 2012 Egypt 24(48) 13(65) 17(34) 5(25) 9(18) 2(10) 65 78 35 22 0.13
  1. The significance level (p-value) for Hardy-Weinberg equilibrium (HWE) testing for controls is shown.