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Table 1 SusR-like and HTCS regulators in B. thetaiotaomicron

From: Polysaccharides utilization in human gut bacterium Bacteroides thetaiotaomicron: comparative genomics reconstruction of metabolic and regulatory networks

Locus tag1

Regulator name2

Orthologs3

Utilized polysaccharides4

HTCS regulators

BT0138

 

4

 

BT0267

HTCS_Aga-1

1

Arabinogalactansb, c

BT0366

HTCS_Ara-1

6

Arabinansa, b

BT0958

 

2

 

BT0981

 

6

Rhamnogalacturonansb, c

BT1635

 

2

N-Acetylglucosamine polymersc

BT1734

 

7

 

BT1754

HTCS_Fru

10

Fructosidesa, b

BT2391

 

1

 

BT2628

HTCS_Man-1

3

Mannansb, c

BT2826

HTCS_Ogl-1

1

O-glycansb, c

BT2860

 

1

 

BT2897

 

5

Arabinansc

BT2923

 

4

 

BT2971

 

1

N-Acetylglucosamine polymersd

BT3049

HTCS_Ara-2

6

Arabinansb, c

BT3097

 

2

Arabinansc

BT3134

 

3

N-Acetylglucosamine polymersd

BT3172

 

2

Mannansa

BT3302

HTCS_Man-2

1

Mannansb, c

BT3334

HTCS_Hya

7

Chondroitin sulfate, Hyaluronanb, c

BT3465

 

3

 

BT3678

 

1

Arabinansc

BT3738

 

3

 

BT3786

HTCS_Man-3

4

Mannansb, c

BT3800

 

3

N-Acetylglucosamine polymersc

BT3951

 

3

 

BT3957

 

3

Mannansc

BT4111

HTCS_Rgu-1

8

Rhamnogalacturonansb, c

BT4124

HTCS_Rgu-1

2

Rhamnogalacturonansb, c

BT4137

HTCS_Ogl-2

1

O-glycansb, c

BT4178

HTCS_Rgu-2

3

Rhamnogalacturonans b, c

BT4182

HTCS_Rgu-2

2

Rhamnogalacturonans b, c

BT4236

 

2

 

BT4663

HTCS_Hep

4

Heparina, b

BT4673

HTCS_Pga

3

Pectic galactanb

SusR-like regulators

BT2160

SusR4

2

 

BT3091

SusR2

5

Dextran b, c

BT3309

SusR3

2

 

BT3705

SusR

6

Starcha

BT4069

 

2

 
  1. For details, see Additional file 1. 1Regulator locus tags are shown for B. thetaiotaomicron VPI-5482. 2Regulator names are shown for only the regulons reconstructed in this study. 3Number of regulator’s orthologs found in 11 analyzed genomes of Bacteroides spp.4Superscript letters show different types of evidence for the predicted polysaccharide utilization pathway that is controlled by studied regulators: (a) in vitro glycan binding to the sensor domain of a regulator; (b) differential expression of sugar utilization genes that are located in the same chromosomal cluster with a regulator gene [28]; (c) bioinformatics analysis of co-localization of a regulator gene with sugar utilization genes.