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Figure 4 | BMC Genomics

Figure 4

From: Recombinant structures expand and contract inter and intragenic diversification at the KIR locus

Figure 4

Linkage disequilibrium and hybrid gene exchange in the telomeric KIR region. (A) Depicted are two major 3DL1/S1 motifs in the telomeric region and their linked genomic sequences indicated with color shading. Supporting phylogenetic analysis of the represented linkage disequilibrium arrangements were found from an examination of all sequenced KIR haplotypes (Additional file2: Figure S2B). Exchange between 3DL1 and 3DS1 connecting 3DS1-intron 5B in tB01 with 3DL1-intron 5B in tA01-1 leads to the generation of hybrid alleles of telomeric 3D genes, as depicted. (B) Essentially similar depiction of 3DL1*007/*008, connecting 3DL1-intron 5B in tA01-1 with 3DL1-intron 5B in tA01-2. Color shading indicates origin of the sequences. For both (A) and (B) red bars within gene structure cartoons represent possible recombination sites in the generation of hybrid genes. Supporting phylogenetic, alignment, and breakpoint analyses are presented in Additional file2: Figures. S2B and S3.

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