Figure 6
From: Recombinant structures expand and contract inter and intragenic diversification at the KIR locus
Putative patterns of exchange in the generation of mutant arrangements of combined motifs in the telomeric region. (A) Exchange between the KIR-cB02|tA01 and KIR-cB02|tB01 haplotypes yields the KIR-cB02|tA01-ins4 and the KIR-cB02|tB01-del6 haplotypes, gaining and losing respectively the 3DP1-2DL4-3DS1 gene block. (B) Exchange between parent haplotypes KIR-cA01|tA01 and KIR-cA01|tB01 yields two KIR mutant haplotypes cA01|tA01-ins5 and cA01|tB01-del7, gaining and losing respectively the 2DL1-partial-3DP1-2DL4-3DS1-2DL5-2DS3-2DS1-partial gene block. The names of haplotypes sequenced in this report are in light gray. The sequence of the cA01|tB01-del7 haplotype was described in a previous report[34]. In both A and B, cartoons depicting the haplotype motif structures are color-coded according to the key at the bottom. Crossed lines indicate putative recombination points with detailed supporting breakpoint and alignment analysis presented in Additional file2: Figure S4.