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Figure 7 | BMC Genomics

Figure 7

From: Recombinant structures expand and contract inter and intragenic diversification at the KIR locus

Figure 7

Putative recombination pathway for transfer of the 2DL5-2DS35 gene block between the centromeric and telomeric motifs. An exchange between the intron 2B regions of 2DL5A (tB01) and 3DP1 (cB02) is depicted, yielding the KIR-cB02|tB01-del6 haplotype. A second exchange between the intergenic regions of 2DS35-2DS1 in KIR-cB02|tB01-del6 and 2DL3/2DS3/S5-2DP1 in the cA01 or cB01 motifs is depicted yielding the cB01 motif with resultant transfer of the 2DL5-2DS35 gene block. Supporting alignment, breakpoint, and phylogenetic analyses for this pathway are presented in Additional file2: Figure S5.

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