Figure 5

Potential molecular mechanisms by which Rpl11 deficiency leads to hematopoietic defects in zebrafish embryos. In this study, we deduced three potential mechanisms by which Rpl11 deficiency leads to hematopoietic defects in zebrafish embryos. First, Rpl11 deficiency led to abnormal expression of a set of iron metabolism- and heme synthesis-related genes. Second, Rpl11 deficiency disturbed proliferation and development of HSCs. Finally, Rpl11 deficiency disturbed several hematopoiesis-associated pathways. Solid lines represent mechanisms that have been confirmed in this or other studies, and dashed lines represent mechanisms that require further validation.