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Table 1 Affected hematological genes in Rpl11-deficient zebrafish embryos at 48 hpf

From: Assessment of hematopoietic failure due to Rpl11 deficiency in a zebrafish model of Diamond-Blackfan anemia by deep sequencing

Genes

Fold change

p-Value

Description

Human homolog

hbbe3

↑3.12

0

Hemoglobin beta embryonic-3

HBE1

hbbe2

↑1.56

3.84E-23

Hemoglobin beta embryonic-2

HBE1

zgc:153284

↑2.32

6.20E-13

zgc:153284

-

cyp26a1

↑3.13

0.001089

Cytochrome P450, subfamily XXVIA, polypeptide 1

CYP26A1

ddx18

↑1.58

0.003224

DEAD (Asp-Glu-Ala-Asp) box polypeptide 18

DDX18

cyp24a1

↑6.16

0.014658

Cytochrome P450, family 24, subfamily A, polypeptide 1

CYP24A1

ptgs2a

↑2.21

0.023441

Prostaglandin-endoperoxide synthase 2a

-

zgc:56493

↓1.63

2.38E-18

zgc:56493

TXN

cox4i1

↓1.52

6.39E-17

Cytochrome c oxidase subunit IV isoform 1

COX4I1

pdia3

↓2.94

1.45E-13

Protein disulfide isomerase family A, member 3

PDIA3

pdia4

↓3.75

7.23E-10

Protein disulfide isomerase associated 4

PDIA4

hdac1

↓1.68

8.99E-08

Histone deacetylase 1

HDAC1

Cat

↓3.66

2.19E-06

Catalase

CAT

rrm2

↓2.04

1.47E-05

Ribonucleotide reductase M2 polypeptide

-

p4hb

↓2.02

2.57E-05

Procollagen-proline, 2-oxoglutarate 4-dioxygenase, beta polypeptide

P4HB

rrm1

↓1.82

3.28E-05

Ribonucleotide reductase M1 polypeptide

RRM1

cyp2aa8

↓2.29

0.000119

cytochrome P450, family 2, subfamily AA, polypeptide 8

-

tp53

↓1.66

0.000172

Tumor protein p53

TP53

agxt2l1

↓4.63

0.000349

Alanine-glyoxylate aminotransferase 2-like 1

AGXT2L1

pdip5

↓2.06

0.000366

Protein disulfide isomerase-related protein (provisional)

PDIA6

alas2

↓1.60

0.000435

Aminolevulinate, delta-, synthetase 2

ALAS2

Max

↓1.88

0.000645

myc-associated factor X

MAX

isca1

↓1.72

0.000755

Iron-sulfur cluster assembly 1

ISCA1

sh3bgrl3

↓2.39

0.002398

SH3 domain binding glutamic acid-rich protein like 3

SH3BGRL3

pgrmc1

↓1.86

0.003269

Progesterone receptor membrane component 1

PGRMC1

snrnp70

↓1.76

0.006001

Small nuclear ribonucleoprotein 70 (U1)

SNRNP70

cyp2aa4

↓2.27

0.007172

Cytochrome P450, family 2, subfamily AA, polypeptide 4

-

mta2

↓1.62

0.009737

Metastasis associated 1 family, member 2

MTA2

sema3d

↓4.42

0.016997

Semaphorin 3d

SEMA3D

txndc5

↓1.53

0.029683

Thioredoxin domain containing 5

TXNDC5

Mb

↓2.85

0.037113

Myoglobin

MB

slc40a1

↓1.96

0.037939

Solute carrier family 40 (iron-regulated transporter), member 1

SLC40A1

pgrmc2

↓1.63

0.038689

Progesterone receptor membrane component 2

PGRMC2

  1. Differentially expressed hematological genes in Rpl11-deficient zebrafish embryos were identified (Fold change >1.5, p-value <0.05).