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Table 2 Frequency of positive cases for MDR1 promoter methylation, distribution of methylation levels in normal prostate tissue and prostate lesions [Median (IQR: interquartile range)], and correlation with histopathological parameters

From: Epigenetic regulation of MDR1 gene through post-translational histone modifications in prostate cancer

  n Frequency (%) p-value* Median (IQR) p-value**
Tissue sample    p < 0.001   p < 0.001
BPH 26 11.5 (3/26)   19.8 (11.9-26.8)  
NPT 10 0 (0/10)   19.0 (14.3–21.9)  
HGPIN 37 37.8 (14/37)   38.6 (28.3–59.2)  
PCa 121 67.8 (82/121)   85.8 (36.6 - 192.0)  
Gleason score    p = 0.142   p = 0.097
<7 54 63.0 (34/54)   67.7 (29.4-158.2)  
7 60 68.3 (41/60)   115.1 (37.6-227.7)  
>7 7 100.0 (7/7)   85.8 (75.6-195.6)  
Tumor stage      p < 0.001
pT2 63 54.0 (34/63) p = 0.001 57.6 (29.4 - 158.2)  
pT3 58 82.8 (48/58)   140.8 (37.6 - 227.7)  
  1. *Chi-square test for trend, **Kruskall–Wallis ANOVA or Mann–Whitney test, as appropriate.
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