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Table 2 Frequency of positive cases for MDR1 promoter methylation, distribution of methylation levels in normal prostate tissue and prostate lesions [Median (IQR: interquartile range)], and correlation with histopathological parameters

From: Epigenetic regulation of MDR1 gene through post-translational histone modifications in prostate cancer

 

n

Frequency (%)

p-value*

Median (IQR)

p-value**

Tissue sample

  

p < 0.001

 

p < 0.001

BPH

26

11.5 (3/26)

 

19.8 (11.9-26.8)

 

NPT

10

0 (0/10)

 

19.0 (14.3–21.9)

 

HGPIN

37

37.8 (14/37)

 

38.6 (28.3–59.2)

 

PCa

121

67.8 (82/121)

 

85.8 (36.6 - 192.0)

 

Gleason score

  

p = 0.142

 

p = 0.097

<7

54

63.0 (34/54)

 

67.7 (29.4-158.2)

 

7

60

68.3 (41/60)

 

115.1 (37.6-227.7)

 

>7

7

100.0 (7/7)

 

85.8 (75.6-195.6)

 

Tumor stage

    

p < 0.001

pT2

63

54.0 (34/63)

p = 0.001

57.6 (29.4 - 158.2)

 

pT3

58

82.8 (48/58)

 

140.8 (37.6 - 227.7)

 
  1. *Chi-square test for trend, **Kruskall–Wallis ANOVA or Mann–Whitney test, as appropriate.