Figure 1

Neuropeptide precursor complement of Platynereis dumerilii . Neuropeptide precursors (pNPs) were classified based on their phylogenetic distribution into eumetazoan, bilaterian, protostome (prot.), lophotrochozoan, annelid and Platynereis-specific. Previously established metazoan pNP families are indicated in bold red [19]. For each pNP we indicated whether a cDNA clone, a full-length ORF sequence, and MS evidence are available. The presence of amidated, Cys-rich, or pyroglutaminated peptides, or a repetitive pNP structure, are also indicated. If a pNP family has multiple Platynereis members, we also indicate the likely origin of this paralog (e.g. {protostome}).