Figure 6

Chromatin characteristics of LUAT-associated promoters in DP thymocytes. Average profiles of ChIP-seq signals of the indicated histone modifications (A) and general transcription factors (B). The 5 kb region around the TSS of the genes included in the indicated sets are shown: LUAT-associated genes, bidirectional coding-gene (coding-coding) and unidirectional genes. The three gene sets were selected ensuring a similar distribution of gene expression levels in DP thymocytes (see Methods). C) Average profile of ChIP-seq signals for H3K79me2 in rescaled region ranging from the TSS to the end of the first intron. D)  Boxplots showing the distribution of reads per bp for H3K79me2 within the region comprising the TSS and the end of the first intron (p-values of the Wilcoxon rank sum test are shown).