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Figure 1 | BMC Genomics

Figure 1

From: Combined ChIP-Seq and transcriptome analysis identifies AP-1/JunD as a primary regulator of oxidative stress and IL-1β synthesis in macrophages

Figure 1

Strategy employed to identify primary JunD targets in bone marrow derived macrophages. We performed Jund RNAi and compared whole genome expression profiling in macrophages (basal and stimulated with LPS, 100ng/ml, 8h) transfected with scrambled siRNA to those transfected with Jund siRNA. ChIP-Seq analysis was performed in WKY and WKY.LCrgn2 BMDMs (basal and stimulated with LPS, 100ng/ml, 2h). Transcripts showing a fold change > 3 in the RNAi dataset were examined for JunD/AP1 peaks.

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BMC Genomics

ISSN: 1471-2164

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