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Figure 6 | BMC Genomics

Figure 6

From: Combined ChIP-Seq and transcriptome analysis identifies AP-1/JunD as a primary regulator of oxidative stress and IL-1β synthesis in macrophages

Figure 6

JunD expression levels control the production of mature IL-1β in BMDMs and nephritic glomeruli. (A) Western blot of mature IL-1β expression in WKY, WKY.LCrgn2, LEW and LEW.WCrgn2 BMDMs primed with LPS and stimulated with ATP. The result of 3 independent experiments is demonstrated alongside β-actin loading control. ELISAs for IL-1β in LPS primed and ATP activated BMDMs (B) and in nephritic glomeruli (C). **P<0.01 statistically significantly different to WKY using a one way-ANOVA with Bonferonni’s post-tests.

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BMC Genomics

ISSN: 1471-2164

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