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Table 3 Gene ontology analysis for genes demonstrating differential expression over the eight hour LPS timecourse between WKY and WKY.L Crgn2 BMDMs

From: Combined ChIP-Seq and transcriptome analysis identifies AP-1/JunD as a primary regulator of oxidative stress and IL-1β synthesis in macrophages

Gene ontology term (BP_FAT or KEGG pathway)

Genes (n)

Fold Enrichment

Bonferroni corrected P-Value

GO:0010033~response to organic substance

84

2.23

9.00E-09

GO:0009725~response to hormone stimulus

53

2.57

1.59E-06

GO:0009611~response to wounding

46

2.68

6.71E-06

GO:0009719~response to endogenous stimulus

53

2.28

9.90E-05

GO:0001775~cell activation

31

3.18

1.08E-04

GO:0043434~response to peptide hormone stimulus

29

3.24

2.22E-04

GO:0050865~regulation of cell activation

25

3.63

2.44E-04

GO:0002237~response to molecule of bacterial origin

21

4.02

6.34E-04

GO:0002694~regulation of leukocyte activation

23

3.49

0.0018

GO:0032496~response to lipopolysaccharide

19

3.95

0.0036

GO:0045767~regulation of anti-apoptosis

11

7.37

0.0039

GO:0045321~leukocyte activation

26

3.04

0.0039

GO:0001817~regulation of cytokine production

22

3.42

0.0047

GO:0009617~response to bacterium

26

3.00

0.0052

GO:0006954~inflammatory response

26

2.98

0.0056

GO:0048545~response to steroid hormone stimulus

31

2.65

0.0058

GO:0043067~regulation of programmed cell death

54

1.96

0.0079

GO:0010941~regulation of cell death

54

1.96

0.0085

GO:0031667~response to nutrient levels

30

2.64

0.0095

GO:0042981~regulation of apoptosis

53

1.95

0.012

GO:0009991~response to extracellular stimulus

31

2.54

0.014

GO:0002684~positive regulation of immune system process

26

2.80

0.018

GO:0051249~regulation of lymphocyte activation

20

3.37

0.020

GO:0007568~aging

20

3.35

0.022

GO:0006952~defense response

36

2.28

0.024

GO:0045768~positive regulation of anti-apoptosis

9

8.03

0.027

GO:0007565~female pregnancy

16

3.94

0.033

GO:0014070~response to organic cyclic substance

24

2.85

0.033

GO:0008283~cell proliferation

27

2.62

0.036

GO:0046649~lymphocyte activation

21

3.09

0.041

GO:0042592~homeostatic process

53

1.86

0.044

  1. Enrichment for biological process functional annotation terms and KEGG canonical pathways used a Bonferroni corrected p-value threshold of <0.05. Abbreviations: BP_FAT, subset of Biological Process Gene Ontology (GO) terms generated by DAVID; n, number of involved genes.
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BMC Genomics

ISSN: 1471-2164

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