Skip to main content
Figure 1 | BMC Genomics

Figure 1

From: A unified approach for allele frequency estimation, SNP detection and association studies based on pooled sequencing data using EM algorithms

Figure 1

Comparison of f ^ em and f ^ avg . An example for the comparison of performances between f ^ em and f ^ avg , where f = 1%, αstart = 1%, n = 3000, K = 100, and G = 10. The two box plots on the left are a comparison between f ^ avg and f ^ em as an estimate of f and f ^ frac , where f ^ avg shows a considerable tendency of over-estimation compared to f ^ em . The upper right histogram shows how f ^ em deviates from f in 1000 simulations, which appears to be roughly unbiasedly distributed around f. The lower right bar plot is a summary plot of the MSE for these two methods as estimates of f and ffrac, showing superiority of f ^ em both as an estimator of f and of ffrac, in terms of MSE and Cg.

Back to article page