Table 3 Biological interpretation about similarity between two fitness profiles
From: FitSearch: a robust way to interpret a yeast fitness profile in terms of drug's mode-of-action
Query fitness profile | Target fitness profile | Biological interpretation of similar target treatment |
|---|---|---|
Chemical-genetic (Hom) | Chemical-genetic (Hom) | Chemical effect (i.e. drug toxicity) with similar mode-of-action |
Chemical-genetic (Het) | Chemical-genetic (Het) | Chemical effect with similar mode-of-action; Finding common direct drug target protein |
Chemical-genetic (Hom) | Genetic-genetic (Hom) | Genetic effect (i.e. knock-out and mutations) on direct drug target protein gene |
Chemical/genetic-genetic (Hom/Het) | Biological functional annotation: -Gene ontology -Protein complexes | Biological functions related to chemical or genetic effect |