From: FitSearch: a robust way to interpret a yeast fitness profile in terms of drug's mode-of-action
Rank | Gene1 | Gene2 | Tc | P-value | Note |
---|---|---|---|---|---|
1 | YPL022W RAD1 | YML095C RAD10 | 1 | 3.44E-29 | Single-stranded DNA endonucleases (with each other) |
2 | YDL040C NAT1 | YHR013C ARD1 | 0.94 | 1.18E-317 | Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p) |
3 | YCR009C RVS161 | YDR388W RVS167 | 0.91 | 3.37E-114 | Manually curated by [27] |
4 | YPL020C ULP1 | YKR082W NUP133 | 0.91 | 3.79E-28 | Overexpression of ULP1 rescues a nup133 rad27 or nup60 rad27 double mutant [28] |
5 | YJL194W CDC6 | YHR118C ORC6 | 0.91 | 1.42E-72 | ORC6-rxl and chromosomal deletion of the Cdc6 leads to slow growth phenotype [29] |
6 | YMR125W STO1 | YPL178W CBC2 | 0.88 | 2.62E-40 | Both are subunits of cap-binding protein complex |
7 | YMR224C MRE11 | YNL250W RAD50 | 0.88 | 1.34E-171 | MRE11 is a subunit of a complex with Rad50p and Xrs2p |
8 | YBR175W SWD3 | YAR003W SWD1 | 0.88 | 4.12E-54 | Both are subunits of the COMPASS (Set1C) complex |
9 | YDR166C SEC5 | YLR166C SEC10 | 0.86 | 2.30E-32 | Both are subunits of the exocyst complex |
10 | YNL041C COG6 | YNL051W COG5 | 0.8 | 1.56E-96 | Both are components of the conserved oligomeric Golgi complex |