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Figure 3 | BMC Genomics

Figure 3

From: GWIS - model-free, fast and exhaustive search for epistatic interactions in case-control GWAS

Figure 3

Power of χ 2 and the proposed DSS heuristic over simulated data. These charts compare the power of χ 2 and the proposed DSS heuristic to detect an epistatic pair. All DSS results are shown as solid lines; χ 2 results are shown as dashed lines. Lines of same colour represent results from different statistics on the same simulated data. The effects of varying heritability, sample size (200, 400, 800, 1600) and minor allele frequency (0.2, 0.4) are shown here. Each data point shows the mean power over 500 randomly generated datasets. Across all parameter configurations DSS demonstrated higher power to detect the interacting pair of SNPs than χ 2 . False-positive rates for both tests (not shown here) were very low and grew linearly with the number of samples (individuals).

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