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Table 4 Overlap between SNP pairs found by GWIS using the DSS filter and previous studies after GSS filtering.

From: GWIS - model-free, fast and exhaustive search for epistatic interactions in case-control GWAS

Disease Lit. total Lit. after GSS Overlap GWIS only GWIS total
BD 134 57 (43%) 56 123 (69%) 179
CAD 117 37 (32%) 37 79 (68%) 116
CD 234 21 (9%) 21 36 (63%) 57
HT 93 53 (57%) 49 58 (54%) 107
RA 293 191 (65%) 190 122 (39%) 312
T1D 801 35 (4%) 35 72 (67%) 107
T2D 230 59 (26%) 56 78 (58%) 134
  1. Overlap between SNP pairs found by GWIS and previous studies. "Lit. total" refers to the number of SNP pairs previously reported. "Lit. after GSS" refers to the number of pairs that remain significant after applying the GSS filter. "Overlap" is the set of pairs detected by GWIS and reported in literature. GWIS only and GWIS total refer to the number of pairs only detected by GWIS and the total number of pairs detected by GWIS respectively. Significance for DSS and GSS is defined by Bonferroni correction ( p - value = 459 , 012 2 - 1 1 0 - 11 ).