Figure 3
From: Collective judgment predicts disease-associated single nucleotide variants
The overlap in sequence profile-based feature distributions is most visible for hardest to predict set of variants. Distributions of the frequencies of the wild-type (Fwt) and mutant (Fm) residues and conservation indices (CI) for disease-related (red) and polymorphic (blue) nsSNVs were computed from sequence profiles. The distributions are calculated on SV-2009 dataset (panels A, B, C) and its subsets: Consensus (panels D, E, F), Majority (panels G, H, I) and Tie (panels J, K, L). Distributions of all profile features overlap most for Tie set and least for Consensus set.