Comparison of VEST with popular methods PolyPhen2 and SIFT4.0. Receiver Operating Characteristic (left) and precision-recall curve (right) for VEST (A), PolyPhen2 (B) and SIFT4.0 (C). The color bar for SIFT is reversed since a low SIFT score corresponds to positive class prediction. ROC AUC is 0.92, 0.85, 0.84 for VEST, PolyPhen2 and SIFT respectively. PR AUC is 0.88, 0.76, 0.72 for VEST, PolyPhen2 and SIFT respectively.