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Table 7 MYH3 and DHODH rankings using different null models.

From: Identifying Mendelian disease genes with the Variant Effect Scoring Tool

Gene FisherRank FisherP FisherBHFDR StoufferRank StoufferP StoufferBHFDR
Swissprot null model       
DHODH 4 3.8e-05 0.05 2 0.001 1.00
MYH3 5 1.7e-05 0.05 4 0.021 1.00
1000 genomes null model       
DHODH 5 4.4e-08 0.05 2 1.9e-06 0.05
MYH3 3 3.8e-14 0.05 2 9.3e-07 0.05
Complete genomics null model       
DHODH 5 4.6e-08 0.05 2 1.9e-06 0.05
MYH3 15 2.0e-06 0.05 5 2.4e-03 1.00
  1. Ranks of MYH3 and DHODH differ slightly when different null models are used to estimate p-values for VEST mutation scores.