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Table 2 Breakdown of the number of mutations in SAAPdb and their mapping to structure.

From: The SAAP pipeline and database: tools to analyze the impact and predict the pathogenicity of mutations

Number of Mutations

PDs

SNPs

Mapped to UniProtKB/SwissProt

13,059

48,452

Mapped to PDB

6,527

17,915

Mapped to multiple PDBs

202,566

33,369

Mapped to multiple Chains

405,497

45,699

  1. In some cases, several hundred structures are available (e.g. haemoglobin, carbonic anhydrase, prthrombin, transthyretin, insulin, CDK2, lysozyme) and, on average there are approximately two copies of each chain in each PDB file.
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BMC Genomics

ISSN: 1471-2164

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