Figure 5

Correlation between position-based DS-Score and Conservation (estimated by Entropy) for mutations in yeast and human. The relationship between position-based DS-Score (using 1.3 as a threshold) and the conservation of the mutated domain position, as estimated by Entropy, is depicted for yeast (A) and human (B) domains. Additionally, the average entropy for each domain is compared with the number of domain hotspots (using 1.3 as a threshold) in yeast (C) or human (D). In this plot, the total number of domain hotspots is compared to the average Entropy of all positions in the domain model.