A protein domain-centric approach for the comparative analysis of human and yeast phenotypically relevant mutations

Table 1 Distribution of yeast and human mutations at functional and conserved sites

	Yeast	Human
Total phenotypically relevant protein mutations	1,490	32,653
Total phenotypically relevant protein mutations inside of domain regions	1,129 (76%)	24,301 (74%)
Total phenotypically relevant domain mutations	11,016	323,840
Domain positions with at least one mutation	8,186	130,731
Domain mutations at functional feature domain sites	3,992 (36%, p-value: ≈ 0)	58,096 (18%, p-value: ≈ 0)
Domain mutations at conserved domain sites	5,950 (45%, p-value: ≈ 0)	152,524 (47%,p-value: ≈ 0)

Counts for yeast and human mutations at functional feature and conserved sites. Fisher's exact test was used to compute the p-values for significant overlap of mutations with the functional and conserved sites.

ISSN: 1471-2164