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Table 2 Distribution of yeast and human domain hotspots at functional features and conserved sites

From: A protein domain-centric approach for the comparative analysis of human and yeast phenotypically relevant mutations

 

Yeast (1.6)

Yeast (1.3)

Yeast (1.0)

Human (1.6)

Human (1.3)

Human (1.0)

Position-based domain hotspots at conserved sites

56 (55%)

64 (56%)

68 (50%)

295 (41%)

346 (39%)

431 (40%)

Feature-based domain hotspots at conserved sites

531 (67%)

582 (67%)

646 (63%)

1,859 (58%)

1,978 (57%)

2,265 (57%)

Position-based domain hotspots at functional features

31 (31%)

35 (31%)

44 (33%)

120 (17%)

137 (16%)

169 (16%)

Feature-based domain hotspots at functional features

721 (91%)

790 (91%)

931 (91%)

2,593 (81%)

2,691 (78%)

3,042 (77%)

  1. The portion of human and yeast DS-Score hotspots at functional feature and conserved sites each threshold level, i.e., 1.6, 1.3, and 1.0.