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Table 5 Mapping of domain hotspots from yeast to known disease mutations in human.

From: A protein domain-centric approach for the comparative analysis of human and yeast phenotypically relevant mutations

 

Domain Hotspot Count (1.6)

Domain Hotspot count (1.3)

Domain Hotspot Count (1.0)

Position-based domain hotspots in yeast

101

114

135

Feature-based domain hotspots in yeast

791

869

1,022

Position-based domain hotspots in yeast that hit at least one human mutation

54 (53.5%, p-value: 2e-26)

56 (49.1%, p-value: 6e-25)

65 (48.8%, p-value: 5e-28)

Feature-based domain hotspots in yeast that hit at least one human mutation

562 (71.1%, p-value ≈ 0)

592 (68.1%, p-value ≈ 0)

666 (65.2%, p-value ≈ 0)

  1. Position-based and feature-based hotspots from yeast that could be associated with a human mutation through a common protein domain position were quantified (P-values from Fisher exact test are shown).
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BMC Genomics

ISSN: 1471-2164

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