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Table 4 Performance of the different methods on the SAP-NEW dataset

From: WS-SNPs&GO: a web server for predicting the deleterious effect of human protein variants using functional annotation

Method

Qtot

P[D]

S[D]

P[N]

S[N]

MCC

AUC

PhD-SNP

0.70

0.77

0.75

0.57

0.61

0.35

0.74

S3D-PROF

0.80

0.80

0.84

0.80

0.76

0.60

0.87

SNPs&GO

0.79

0.84

0.83

0.71

0.71

0.54

0.85

SNPs&GO3d

0.83

0.84

0.86

0.84

0.80

0.67

0.91

  1. D=disease related, N=neutral. For index definition see "Measures of performance