Skip to main content
Figure 6 | BMC Genomics

Figure 6

From: Assessment of computational methods for predicting the effects of missense mutations in human cancers

Figure 6

Proportion of true positives and true negatives above certain score thresholds and corresponding score distributions. Cumulative distributions of true positives and true negatives above certain score cutoffs form the basis for the derivation of weights for our metapredictors. In many cases calculated optimal cutoffs (marked in green) were similar to recommendations from the developers of the tools (marked in red). Both the cumulative distributions and the associated score distributions varied highly between the methods. We transformed raw scores of Snap and MutationAssessor, so that the minimum score is zero.

Back to article page