Table 1 Prediction accuracies, sensitivities, specificities, AUC values and Matthew's correlation coefficients (MCC) compared between methods (based on COSMIC dataset)
Tool | Accuracy | Sensitivity | Specificity | AUC | MCC |
|---|---|---|---|---|---|
CHASM | 89% | 79% | 99% | 0.92 | 0.79 |
MutationAssessor | 81% | 76% | 86% | 0.89 | 0.62 |
Condel | 78% | 75% | 82% | 0.85 | 0.58 |
PolyPhen-2 | 77% | 79% | 75% | 0.82 | 0.54 |
SIFT | 76% | 70% | 82% | 0.80 | 0.52 |
SNAP | 68% | 55% | 81% | 0.67 | 0.37 |
mCluster | 65% | 40% | 90% | 0.64 | 0.35 |
logRE | 61% | 65% | 57% | 0.60 | 0.22 |