Figure 5

(A) Percentage of genes tumor-suppressors affected by both predicted functional mutations and truncating mutations increases with the increase of the predicted functional impact of missense mutations discovered in each of six TCGA projects [3–6, 10, 11]. (B) Percentage of genes affected by both predicted functional mutations and truncating mutations computed for different gene groups in glioblastoma (brain) cancer [6]. "All" stands for mutations affecting all genes; TS, OG, CG, nCG, stand for mutations affecting, respectively, annotated tumor-suppressors, annotated oncogenes, annotated cancer genes, genes with no cancer annotations.