Table 1 Percentage of silent (SM) and truncating mutations (TM) affecting genes with different copy number alterations

breast

CNA:

13

64

21

2

SM:

12

65

22

2

TM:

17

64

18

2

<10-6

1.0E-06

lung

CNA:

12

63

22

3

SM:

11

63

22

3

TM:

13

62

22

3

2.1E-05

3.9E-01

colon

CNA:

12

71

17

1

SM:

11

71

17

1

TM:

14

72

14

1

1.1E-03

4.2E-04

brain

CNA:

14

76

8

3

SM:

13

76

8

3

TM:

15

75

7

2

9.0E-06

4.9E-02

kidney

CNA:

12

76

11

0

SM:

10

76

14

1

TM:

16

71

12

0

<10-6

1.2E-01

ovarian

CNA:

23

51

24

2

SM:

21

53

24

2

TM:

30

49

19

2

<10-6

<10-6