Figure 1
From: Sequence and structure based models of HIV-1 protease and reverse transcriptase drug resistance
Y181C mutant of HIV-1 RT in complex with the NNRTI nevirapine. Shown are residues of the catalytic p66 subunit of RT that are within 5 angstroms of the inhibitor. Major mutations associated with nevirapine resistance occur at positions K103, V106, Y181, Y188, and G190; minor mutations occur at L100, K101, and several additional positions that are more distant from the inhibitor binding site. The diagram is based on atomic coordinates provided by Protein Data Bank (PDB) accession code 1jlb.