Figure 2
From: Sequence and structure based models of HIV-1 protease and reverse transcriptase drug resistance
Elucidation of structure-function relationships in HIV-1 PR and RT. Residual scores of mutant proteins in the inhibitor datasets quantify sequence-structure compatibility changes, whereas corresponding mutant susceptibilities to inhibitors identify functional consequences. Results averaged over datasets comprising each inhibitor class (PIs/NRTIs/NNRTIs) separately, as well as collectively over all classes.