Figure 4
From: Sequence and structure based models of HIV-1 protease and reverse transcriptase drug resistance
Graphical summary of the structure-based study methodology. A structure-based approach makes use of a computational mutagenesis methodology to generate attributes for feature vectors representing HIV-1 RT mutants. Mutants with known phenotypes (levels of susceptibility to various inhibitor drugs) are used to train predictive classification and regression models of drug resistance.