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Figure 4 | BMC Genomics

Figure 4

From: Analysis of schizophrenia and hepatocellular carcinoma genetic network with corresponding modularity and pathways: novel insights to the immune system

Figure 4

IL-2 and TREM-1/DAP12 pathway. A specific gene set of schizophrenic over-expression genes includes SIRPB1, LCK and SYK. Strong correlations with immune system pathways were found which involve the IL-2 and TREM-1/DAP12 pathway which are responsible for etiology mechanism for schizophrenia in PID. The SIRPB1 protein interacts with the glycoprotein DAP12 to induce the signal transduction and the formation of the SIRPB1/DAP12 complex, and then transduces signals to the nucleus with the activation of SYK. Activation of DAP12 and triggering of the TREM-1 receptor result in the production of pro-inflammatory cytokines including interleukin family cytokines, TNF-a, and GM-CSF, etc.

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