Global MRAN and co-occurrence graph of regulators on MRAN. (A) Global MRAN. Nodes of the network represent miRNAs, and edges represent condition-specific cooperativity between a miRNA pair. (B) Co-occurrence graph of regulators on MRAN. In the co-occurrence graph of regulators on MRAN, nodes represent transcription factors (TFs), and edges statistical significance of co-occurrences. The colors of edges indicate different conditions (red: circadian rhythm, blue: radiation treatment, yellow: Actinomycin D treatment, green: prostate adenocarcinomas).