Figure 4

Proximal co-occurrence of motifs with target TF canonical motifs. Significant TF specific co-occurrences of TF motifs with ChIP targeted TF canonical motifs in ChIP-seq peaks. Shown on the x-axis are the individual ChIP-seq experiments and presence of selected motifs in ChIP-seq peaks of these experiments is reflected on the y-axis. In black are ChIP-seq experiments targeting TFs which show high similarity with the motif in question. Colors represent the TF targeted for the ChIP-seq experiment. Known associations identified include the motifs belonging to AP1, ARG81, Jundm2 secondary, Fos and GCN4 which were enriched in peaks where STAT3 was the target TF. Similarly those of HAP3, 4, 5 and NYFA were found enriched in peaks where SP1 was the target TF. Examples of novel TF specific enrichments include EBF1 with NFKB and Plagl1 with c-Myc.