Figure 8
From: Genome-wide structural modelling of TCR-pMHC interactions
Detailed binding model of TCR-peptide interface and amino acid composition of homologous peptide antigen derived from the template. (A) Detailed binding model of TCR-peptide interface derived from the template (i.e. PDB entry: 1lp9). The amino acid compositions (profiles) of the homologous peptide antigens derived from the (B) iMatrix and (C) one-matrix. The position 5 in peptide prefer the aromatic residues (Phe, Tyr, and Trp) proposed by iMatrix. Therefore, the F5V is too small to stabilize van der Waals environments in the pocket.