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Figure 4 | BMC Genomics

Figure 4

From: ITGA6 gene silencing by RNA interference modulates the expression of a large number of cell migration-related genes in human thymic epithelial cells

Figure 4

Cell migration-related networks potentially affected by knocking-down the ITGA6 gene in the human thymic epithelium. Panel a depicts the ITGA6 gene and the selected experimental down- or up-regulated gene expression (green and red spheres, respectively), corresponding to integrin as well as laminin chains. Panel b shows the network of interactions involving ITGA6 and chemokines genes that have been experimentally down- or up-regulated after ITGA6 knock-down. Networks of potential interactions were drawn within the framework of the GeneMANIA database (http://www.genemania.org). Accordingly, each line represents a given type of functional association, available in the literature derived from various biological systems and adopted by GeneMANIA algorithm. Green lines = physical interactions; violet lines = co-expression; orange lines = co-localization; blue lines = metabolic pathways; pink lines = genetic interactions. The thicker is each line, the closer is the weight of association of the two given genes to each other. Overall panel a indicates that the up- or down genes, experimentally defined may them cross-interact, thus impacting the cascade of changes induced by this single gene knock-down in the human thymic epithelium. Additionally, panel b suggests that most of the changes seen in chemokine gene modulation occur via the changes directly induced upon the expression of CXCL2 and IL18.

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