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Figure 4 | BMC Genomics

Figure 4

From: Mature Epitope Density - A strategy for target selection based on immunoinformatics and exported prokaryotic proteins

Figure 4

MED score limitation. Boxplot of pairs of numerators and denominators within the 60 lowest and highest MED scores from the Mtb H37Rv exported proteins. "Predicted" stands for epitope predictions and "Chances" stands for possible 9mers windows in an amino acid sequence's mature portion; both are used in Equation 1. This graph illustrates the major limitation of MED scores: a factor greater than five between the numerator and denominator of a MED score calculation can cover an antigenic protein creating a false negative.

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