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Table 1 MED highest-scored proteins.

From: Mature Epitope Density - A strategy for target selection based on immunoinformatics and exported prokaryotic proteins

Genome

Locus

N

d

MED

(nM/mer)

Local

Evidence

Unique publication identifier

Rv2452c

14

18

27,00

SEC

favorable

10.1046/j.1365-2958.1999.01593.x

Rv1811

66

108

21,34

PSE

favorable

PMID:10760138

Rv3018c

145

234

20,72

PSE

favorable

10.1099/jmm.0.47565-0, 10.1046/j.1365-2958.1999.01593.x, 10.1016/j.vaccine.2004.08.046

Rv1489

37

63

20,36

PSE

favorable

10.1186/1471-2180-10-132, 10.1021/pr0500049, 10.1016/j.tube.2008.01.003

Rv0847

58

98

19,89

SEC

favorable

10.1016/j.tube.2006.01.014, 10.1016/j.tube.2006.01.014

Rv0436c

78

123

19,14

PSE

favorable

10.1074/jbc.M004658200

Rv0116c

117

214

17,61

SEC

favorable

10.1099/mic.0.024802-0

Rv1841c

167

308

17,33

PSE

favorable

10.1128/jb.184.4.1112-1120.2002

Rv2339

224

437

17,25

PSE

favorable

10.1093/molbev/msm111

Rv0589

195

364

17,10

PSE

favorable

10.1007/s11010-011-0733-5

Rv1158c

107

189

17,07

SEC

favorable

10.1016/j.tube.2004.09.005

Rv0286

129

242

17,04

PSE

favorable

10.1128/IAI.70.12.6996-7003.2002

Rv3497c

161

314

16,87

SEC

favorable

10.1073/pnas.1631248100

Rv1967

151

305

16,53

SEC

favorable

10.1111/j.1574-695X.2010.00677.x

Rv1620c

156

311

16,52

PSE

favorable

10.1073/pnas.1003219107, 20090285847

Rv3000

86

167

16,04

PSE

favorable

10.1016/j.tube.2006.01.014

Rv2690c

64

126

16,03

PSE

favorable

Patent 7393540

Rv0804

87

175

15,85

SEC

favorable

10.1107/S1744309108031679

Rv0598c

58

104

15,85

SEC

favorable

PMID:12657046

Rv3693

203

404

15,69

SEC

favorable

10.4049/jimmunol.1002212, 10.1002/pmic.200600853

Rv2262c

100

206

15,69

PSE

favorable

PMID:12368431

  1. Table 1 lists 21 of the 30 highest MED scored-proteins from the Mtb H37Rv exported proteins. Each protein is accompanied by at least a unique publication identifier, which can be doi, Pubmed id or a patent number. A protein can be cited twice or thrice by different publications; some publications cite several proteins. The first columns show the protein locus tags, followed by the number of predicted epitopes (n) and epitope probability as a function of its proportion in the mature protein (d). The MED score is calculated as n divided by d. Evidence can be favorable or contrary based on publication results and the expectation indicated by the MED score.