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Table 1 MED highest-scored proteins.

From: Mature Epitope Density - A strategy for target selection based on immunoinformatics and exported prokaryotic proteins

Genome
Locus
N d MED
(nM/mer)
Local Evidence Unique publication identifier
Rv2452c 14 18 27,00 SEC favorable 10.1046/j.1365-2958.1999.01593.x
Rv1811 66 108 21,34 PSE favorable PMID:10760138
Rv3018c 145 234 20,72 PSE favorable 10.1099/jmm.0.47565-0, 10.1046/j.1365-2958.1999.01593.x, 10.1016/j.vaccine.2004.08.046
Rv1489 37 63 20,36 PSE favorable 10.1186/1471-2180-10-132, 10.1021/pr0500049, 10.1016/j.tube.2008.01.003
Rv0847 58 98 19,89 SEC favorable 10.1016/j.tube.2006.01.014, 10.1016/j.tube.2006.01.014
Rv0436c 78 123 19,14 PSE favorable 10.1074/jbc.M004658200
Rv0116c 117 214 17,61 SEC favorable 10.1099/mic.0.024802-0
Rv1841c 167 308 17,33 PSE favorable 10.1128/jb.184.4.1112-1120.2002
Rv2339 224 437 17,25 PSE favorable 10.1093/molbev/msm111
Rv0589 195 364 17,10 PSE favorable 10.1007/s11010-011-0733-5
Rv1158c 107 189 17,07 SEC favorable 10.1016/j.tube.2004.09.005
Rv0286 129 242 17,04 PSE favorable 10.1128/IAI.70.12.6996-7003.2002
Rv3497c 161 314 16,87 SEC favorable 10.1073/pnas.1631248100
Rv1967 151 305 16,53 SEC favorable 10.1111/j.1574-695X.2010.00677.x
Rv1620c 156 311 16,52 PSE favorable 10.1073/pnas.1003219107, 20090285847
Rv3000 86 167 16,04 PSE favorable 10.1016/j.tube.2006.01.014
Rv2690c 64 126 16,03 PSE favorable Patent 7393540
Rv0804 87 175 15,85 SEC favorable 10.1107/S1744309108031679
Rv0598c 58 104 15,85 SEC favorable PMID:12657046
Rv3693 203 404 15,69 SEC favorable 10.4049/jimmunol.1002212, 10.1002/pmic.200600853
Rv2262c 100 206 15,69 PSE favorable PMID:12368431
  1. Table 1 lists 21 of the 30 highest MED scored-proteins from the Mtb H37Rv exported proteins. Each protein is accompanied by at least a unique publication identifier, which can be doi, Pubmed id or a patent number. A protein can be cited twice or thrice by different publications; some publications cite several proteins. The first columns show the protein locus tags, followed by the number of predicted epitopes (n) and epitope probability as a function of its proportion in the mature protein (d). The MED score is calculated as n divided by d. Evidence can be favorable or contrary based on publication results and the expectation indicated by the MED score.