Overview of workflow. (A) GO-based gene co-expression network construction. It has five steps: (1) Raw microarray data processing and analysis. (2) GO term expression data matrix-building. (3) Pairwise correlation analysis of genes in GO term across different samples. (4) Expression profile clustering and module identification using WGCNA. (5) Visualization of co-expression modules by Cytoscape. (B) Framework of module significance analyses. The details are provided in Methods.